Dogs 5-24 lbs. Advanced oral care. Loved since 1908. As effective as brushing (When fed daily, Milk-Bone Brushing Chews are as effective as brushing a dog's teeth twice a week based on the reduction of tartar build-up. The Veterinary Oral Health Council recommends daily tooth brushing for optimal effectiveness). Good oral care helps your dog live a healthy, happy life. See bottom panel for details. Nubs & ridges designed to help clean like bristles on a toothbrush. Fights tartar build-up and bad breath. Daily Milk-Bone Brushing Chews. Yearly veterinary dental checkup. Dental Twist Bone helps clean even hard to reach back teeth and down to the gumline. Veterinary Oral Health Council. VOHC accepted. Helps control tartar. See bottom panel for product information. For dogs 5-24 lbs. Not suitable for dogs less than 5 lbs, greater than 24 lbs or dogs less than 6 months of age. Fortified with 12 essential vitamins and minerals, including calcium to help support strong bones and teeth. Calorie Content (Calculate): Metabolizable Energy (ME) 2580 kcal/kg; 31 kcal/piece. Comments or questions? Call 1-888-MilkBone (645-5266), weekdays. Please provide manufacturing code. www.milkbone.com. Produced in Topeka, Kansas, USA.