Clinically proven safe and effective. Caffeine free. Starts to work after just one dose. Eliminate water weight due to premenstrual and menstrual bloat, water weight gain, puffiness and tenderness. Aqua-Ban contains a clinically proven safe and effective yet gentle diuretic for the relief of premenstrual and menstrual bloat and water weight gain. Aqua-Ban works fast and effectively to help your body eliminate excess water so you'll look and feel like yourself again. Made in U.S.A.